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Michael Housman's avatar

Really interesting! Hadn't heard of most of these, although I did try salvia once upon a time (in college) and my experience was similar to what you described: falling over furniture. But it's interesting to think about which ones get popular and why.

Andrew M. Weisse's avatar

Thanks, man. Yep...there is a long list of Psychedelics that never made it. History remembers the winners!

The Reverend Gonzo's avatar

When I was in high school we used to watch a news broadcast on something called Channel 1 news that was hosted by teenagers. I've always remembered one episode they did that showed Indians in the Amazon having Yopo blown into their sinus cavities via someone else using a hollowed out stick, been 30 years and I still have the image in my mind, maybe it's a sign I should try Yopo! May be wrong but from what I remember it's effects are something like Ayahuasca and the Yopo absolutely burns the shit out of your sinuses.

Andrew M. Weisse's avatar

Yep...Yopo is insufflated as you describe. I've never done it but heard its intense. Check out the Yopo Prophecy Murders...wild story involving this relatively obscure Psychedelic!

Harrison Shields's avatar

Has anyone had a good experience with morning glory seeds? A long time ago I bought a bunch of them and tried some of the extraction methods I found online several times to no effect at all. Then I decided to just chew them up. Definitely had a slight psychedelic effect but also felt pretty queasy. Not something I wanted to do again.

Ryan Hightower's avatar

I appreciate your writing, but this analysis fell pretty flat for me. If a substance is unpredictable, difficult or especially dangerous, those are all really good reasons to leave them behind. That's called natural selection.

I also find your list "abandoned" psychedelics pretty misleading. Some of the plants you describe are just the same substance in a different form. For example, the active ingredient in the Yopo tree is just a natural form of DMT. it's not that DMT was abandoned, it's just that there are easier and more abundant sources of DMT, like mamosa bark.

Last but not least, while I agree that marketing is too often a big factor in people's decision, awareness is necessary for any new discovery. I do consider natural curiosity a type of "calling" that can be an important doorway to new discovery, and I personally find it at best introduction and at worst demeaning to dismiss someone's natural curiosity because they describe it in a way that makes you uncomfortable such as "the plant is calling to me."

Just my two cents. Appreciate all you do. Be blessed.

Andrew M. Weisse's avatar

Your explanation is incomplete…natural selection explains some of the story, certainly not all of it. History selected for far more than pharmacology alone.

Also, Yopo isn't "just DMT." Different compounds, methods of administration & cultural histories.

People can describe their curiosity however they like…I simply reject the idea that certain plants are uniquely "calling" while hundreds of forgotten psychoactive plants weren't. That’s unserious thinking.